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3-Bromopyruvic acid
CAS No. 1113-59-3
3-Bromopyruvic acid( Bromopyruvic acid | Hexokinase II Inhibitor II 3-BP )
Catalog No. M20515 CAS No. 1113-59-3
3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 37 | In Stock |
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| 1G | 43 | In Stock |
|
Biological Information
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Product Name3-Bromopyruvic acid
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NoteResearch use only, not for human use.
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Brief Description3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
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Description3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
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In VitroCell Viability Assay Cell Line:MCF-7 and MDA-MB-231 cells Concentration:40, 80, 160 or 320 μM Incubation Time:24 hours Result:3-Bromopyruvate (80 and 160 μmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
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In VivoAnimal Model:Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)Dosage:8 mg/kg Administration:I.p.; every 4 days for 28 days Result:Showed antitumor efficacy in tumor xenografts.
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SynonymsBromopyruvic acid | Hexokinase II Inhibitor II 3-BP
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PathwayOthers
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TargetOther Targets
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Recptorhexokinase II
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Research AreaCancer
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Indicationantineoplastic
Chemical Information
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CAS Number1113-59-3
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Formula Weight166.96
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Molecular FormulaC3H3BrO3
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Purity>98% (HPLC)
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SolubilityH2O:32 mg/mL (191.66 mM)
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SMILESOC(=O)C(=O)CBr
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Leng X Peng J Yu X et al. 3-Bromopyruvic Acid A Hexokinase II Inhibitor is an Effective Antitumor Agent on the Hepatoma Cells : in vitro and in vivo Findings[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 2014 14(5):-.
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