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3-Bromopyruvic acid

CAS No. 1113-59-3

3-Bromopyruvic acid( Bromopyruvic acid | Hexokinase II Inhibitor II 3-BP )

Catalog No. M20515 CAS No. 1113-59-3

3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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500MG 37 In Stock
1G 43 In Stock
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Biological Information

  • Product Name
    3-Bromopyruvic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
  • Description
    3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
  • In Vitro
    Cell Viability Assay Cell Line:MCF-7 and MDA-MB-231 cells Concentration:40, 80, 160 or 320 μM Incubation Time:24 hours Result:3-Bromopyruvate (80 and 160 μmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
  • In Vivo
    Animal Model:Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)Dosage:8 mg/kg Administration:I.p.; every 4 days for 28 days Result:Showed antitumor efficacy in tumor xenografts.
  • Synonyms
    Bromopyruvic acid | Hexokinase II Inhibitor II 3-BP
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hexokinase II
  • Research Area
    Cancer
  • Indication
    antineoplastic

Chemical Information

  • CAS Number
    1113-59-3
  • Formula Weight
    166.96
  • Molecular Formula
    C3H3BrO3
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:32 mg/mL (191.66 mM)
  • SMILES
    OC(=O)C(=O)CBr
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Leng X Peng J Yu X et al. 3-Bromopyruvic Acid A Hexokinase II Inhibitor is an Effective Antitumor Agent on the Hepatoma Cells : in vitro and in vivo Findings[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 2014 14(5):-.
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